Neural Adaptation Leads to Cognitive Ethanol Dependence

نویسندگان

  • Brooks G. Robinson
  • Sukant Khurana
  • Anna Kuperman
  • Nigel S. Atkinson
چکیده

Physiological alcohol dependence is a key adaptation to chronic ethanol consumption that underlies withdrawal symptoms, is thought to directly contribute to alcohol addiction behaviors, and is associated with cognitive problems such as deficits in learning and memory. Based on the idea that an ethanol-adapted (dependent) animal will perform better in a learning assay than an animal experiencing ethanol withdrawal will, we have used a learning paradigm to detect physiological ethanol dependence in Drosophila. Moderate ethanol consumption initially degrades the capacity of larvae to learn, but they eventually adapt and are able to learn as well as ethanol-naive animals. However, withholding ethanol from ethanol-adapted larvae impairs learning. Ethanol reinstatement restores the capacity to learn, thus demonstrating cognitive dependence on ethanol. The larval nervous system also shows ethanol-withdrawal hyperexcitability. Larvae reach ethanol concentrations equivalent to 0.05 to 0.08 blood-alcohol concentration-levels that would be mildly intoxicating in humans. These ethanol-induced changes in learning are not the product of sensory deficits or state-dependent learning. This is the first demonstration of cognitive ethanol dependence in an invertebrate genetic model system.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Alcoholism – the Worst Addiction

Introduction: The most common substance of abuse/dependence in patients presenting for treatment in western countries is alcohol. Ethyl alcohol or ethanol which is also called medicinal alcohol is used as an official drug compendium. It is also administered as an antidote in methanol poisoning. However, regular consumption of high amounts of alcoholic drinks induces dependence and addiction lea...

متن کامل

Alcohol Addiction: Chronic Ethanol Leads to Cognitive Dependence in Drosophila

Recent studies have found that Drosophila show detrimental effects of withdrawal from ethanol on learning, a preference for stimuli associated with intoxication, and a tendency to consume ethanol after frustrating social situations.

متن کامل

The Relationship between Metacognitive Beliefs with the Level of Individual- Social Adaptability among Iran University of Medical Sciences Librarians

Background and Aim: The purpose of this study was to investigate the relationship between meta-cognitive beliefs with individual-social adaptability among Iran University of Medical Sciences librarians. Materials and Methods: The research method was descriptive correlational. The statistical population of this study was 51 librarians of Iran University of Medical Sciences. The research tool wa...

متن کامل

Gene expression changes in a zebrafish model of drug dependency suggest conservation of neuro-adaptation pathways.

Addiction is a complex psychiatric disorder considered to be a disease of the brain's natural reward reinforcement system. Repeated stimulation of the 'reward' pathway leads to adaptive changes in gene expression and synaptic organization that reinforce drug taking and underlie long-term changes in behaviour. The primitive nature of reward reinforcement pathways and the near universal ability o...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Current Biology

دوره 22  شماره 

صفحات  -

تاریخ انتشار 2012